Why the study?
Does angiotensin II potentiate norepinephrine-induced vasoconstriction in isolated canine mesenteric arteries?
Population
Isolated canine mesenteric arteries perfused with Krebs' solution at 37 degrees C
Comparison
Angiotensin II with or without indomethacin vs Norepinephrine and KCl without angiotensin II…
Design
Preclinical
Authors
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Supports angiotensin II modulation of vascular tone in canine models; leaves open translation to human physiology or therapy.
Does angiotensin II potentiate norepinephrine-induced vasoconstriction in isolated canine mesenteric arteries?
Angiotensin II potentiates norepinephrine-induced vasoconstriction in canine mesenteric arteries, likely by modifying intracellular calcium movements and prostaglandin production.
Chiba et al. (1986) studied this question.
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