Key result
Equipressor doses of angiotensin III and angiotensin II similarly inhibited the baroreceptor-cardioinhibitory reflex and central vagal pathways in sheep and dogs.
Why the study?
Does angiotensin III inhibit central vagal pathways to the same extent as angiotensin II in dogs and sheep?
Population
Unanaesthetized sheep and anaesthetized dogs
Comparison
Angiotensin III (equipressor doses) vs Angiotensin II (equipressor doses)
Design
Preclinical
Authors
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Challenges prior reports of differential central actions; leaves open human baroreflex relevance.
Does angiotensin III inhibit central vagal pathways to the same extent as angiotensin II in dogs and sheep?
Angiotensin III and angiotensin II similarly inhibit central vagal pathways, demonstrating shared central nervous system actions on the baroreceptor reflex.
Lumbers et al. (1983) studied this question. Angiotensin III vs. Angiotensin II was evaluated on Inhibition of the baroreceptor-cardioinhibitory reflex and cardiac vagal activity. Equipressor doses of angiotensin III and angiotensin II similarly inhibited the baroreceptor-cardioinhibitory reflex and central vagal pathways in sheep and dogs.
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