What question did this study set out to answer?

The study aims to investigate how intravertebral infusion of angiotensin II affects cardiac vagal efferent activity.

March 28, 2008Neuroendocrinology

Intravertebral Angiotensin II Inhibits Cardiac Vagal Efferent Activity in Dogs

Q: What is the clinical evidence from this study?

Study design: Other. Intervention: Intravertebral infusion of angiotensin II vs. Intravenous and intracarotid infusion of angiotensin II. Primary outcome: Cardiac vagal efferent activity and basal vagal tone.

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Key result

Intravertebral infusion of angiotensin II at doses as low as 5 ng/kg/min inhibited basal vagal tone compared to intravenous or intracarotid infusion in anesthetized dogs.

Why the study?

Does intravertebral angiotensin II inhibit cardiac vagal efferent activity in anesthetized dogs?

Population

Anesthetized mongrel dogs

Comparison

Unilateral intravertebral infusion of… vs Intravenous and intracarotid infusion of similar…

Design

Preclinical

Authors

EPErica K. PotterThe University of Sydney IRIan A. ReidUniversity of Nebraska at Omaha

Discussion

Member takes

Implication

Central angiotensin II inhibits vagal tone in dogs; leaves open its role in human autonomic regulation.

Key Points

The study aims to investigate how intravertebral infusion of angiotensin II affects cardiac vagal efferent activity.
Anesthetized mongrel dogs received unilateral infusion of angiotensin II at 5 ng/kg/min.
Cardiac vagal tone and its relationship with systolic blood pressure were evaluated.
Intravenous and intracarotid infusions of angiotensin II were also tested.
Intravertebral angiotensin II infusion inhibited basal vagal tone significantly.
A decrease in the slope between cardiac vagal efferent activity and systolic blood pressure was observed.
Intravenous and intracarotid infusions had little to no effect on vagal tone.

Structured PICO

Does intravertebral angiotensin II inhibit cardiac vagal efferent activity in anesthetized dogs?

Population

Anesthetized mongrel dogs evaluated for the physiological effects of intravertebral angiotensin II on cardiac vagal efferent activity.

Intervention

Unilateral intravertebral infusion of angiotensin II (doses as low as 5 ng/kg/min)

Comparator

Intravenous and intracarotid infusion of similar doses of angiotensin II

Outcome

Cardiac vagal efferent activity (basal vagal tone and slope of relationship with systolic blood pressure)surrogate

Angiotensin II can act centrally via the vertebral circulation to inhibit cardiac vagal efferent activity, contributing to its hypertensive effects.

Cite This Study

Potter et al. (2008) studied this question. Intravertebral infusion of angiotensin II vs. Intravenous and intracarotid infusion of angiotensin II was evaluated on Cardiac vagal efferent activity and basal vagal tone. Intravertebral infusion of angiotensin II at doses as low as 5 ng/kg/min inhibited basal vagal tone compared to intravenous or intracarotid infusion in anesthetized dogs.

synapsesocial.com/papers/6a6da64b439bab0cabc29511 https://doi.org/10.1159/000124120

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Intravertebral Angiotensin II Inhibits Cardiac Vagal Efferent Activity in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Intravertebral Angiotensin II Inhibits Cardiac Vagal Efferent Activity in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider