June 1, 1995AJP Heart and Circulatory Physiology

Analysis of responses to angiotensin peptides in the hindquarters vascular bed of the cat

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Population

Cat hindquarters vascular bed model

Comparison

Angiotensin peptides (angiotensin I, II, III… vs Norepinephrine, U-46619, and effects of…

Design

Preclinical

Authors

EGEtoi GarrisonVanderbilt Health JSJosé A. SantiagoHospital Arnau de Vilanova SOSuzette Y. OseiTulane University

Discussion

Member takes

Implication

Extends angiotensin peptide potency data in feline vasculature; human relevance and therapeutic implications remain undetermined.

Structured PICO

Population

Cat hindquarters vascular bed model

Intervention

Angiotensin peptides (angiotensin I, II, III, IV, des-Asp1-angiotensin I, and (p-amino-Phe6)-angiotensin II)

Comparator

Norepinephrine, U-46619, and effects of antagonists (DuP-532, PD-123,319, captopril)

Outcome

Increases in perfusion pressuresurrogate

In the feline hindquarters vascular bed, various angiotensin peptides produce similar AT1 receptor-mediated vasoconstriction, with rapid local conversion of substrates into active peptides.

Cite This Study

Garrison et al. (1995) studied this question.

synapsesocial.com/papers/6a8d0ec1102b31c982dacd50 https://doi.org/10.1152/ajpheart.1995.268.6.h2418

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Analysis of responses to angiotensin peptides in the hindquarters vascular bed of the cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Analysis of responses to angiotensin peptides in the hindquarters vascular bed of the cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider