What does this research mean for the field?

[Pro11,D-Ala12]angiotensin I exhibits rapid-onset vasoconstrictor activity in the cat hindlimb vascular bed that is mediated by AT1 receptors and is independent of angiotensin-converting enzyme activity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1997AJP Endocrinology and Metabolism

Pro11,d-Ala12angiotensin I has rapid onset vasoconstrictor activity in the cat

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Population

Cat hindlimb vascular bed model

Comparison

[Pro11,D-Ala12]angiotensin I injections vs Angiotensin I, Angiotensin II, and various…

Design

Preclinical

Authors

EGEtoi GarrisonVanderbilt Health HCHunter C. ChampionHeart Failure & Transplant PKPhilip J. KadowitzMarquette University

Discussion

Member takes

Implication

Reveals ACE-independent AT1 vasoconstriction in animal vasculature; leaves open relevance to human hypertension pathways.

Structured PICO

Population

Cat hindlimb vascular bed model

Intervention

[Pro11,D-Ala12]angiotensin I injections (1-300 micrograms)

Comparator

Angiotensin I, Angiotensin II, and various antagonists (captopril, DUP-532, candesartan, PD-123319)

Outcome

Changes in perfusion pressure (vasoconstrictor activity)surrogate

The synthetic substrate [Pro11,D-Ala12]angiotensin I exhibits rapid, AT1 receptor-mediated vasoconstrictor activity in the cat hindlimb vascular bed, independent of angiotensin-converting enzyme action.

Cite This Study

Garrison et al. (1997) studied this question.

synapsesocial.com/papers/6a12eaa083732aa7db9e8dbd https://doi.org/10.1152/ajpendo.1997.273.6.e1059

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Pro11,d-Ala12angiotensin I has rapid onset vasoconstrictor activity in the cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pro11,d-Ala12angiotensin I has rapid onset vasoconstrictor activity in the cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider