February 1, 1995AJP Lung Cellular and Molecular Physiology

Analysis of responses to ANG IV: effects of PD-123319 and DuP-753 in the pulmonary circulation of the rat

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Population

Isolated blood-perfused rat lung model

Comparison

Angiotensin IV administration, with or without… vs Angiotensin I, II, III, bradykinin, serotonin…

Design

Preclinical

Authors

BNBobby D. NossamanOchsner Health System CFChang J. FengDalian Medical University AKAlan D. KayeAin Shams University

Discussion

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Implication

Should not alter clinical management of pulmonary hypertension; hypothesis-generating for AT1/AT2 roles in human lung vasculature.

Structured PICO

Population

Isolated blood-perfused rat lung model

Intervention

Angiotensin IV (ANG IV) administration, with or without AT1/AT2 receptor antagonists (DuP-753, PD-123319) and other modulators (captopril, enalaprilat, meclofenamate, L-NAME)

Comparator

Angiotensin I, II, III, bradykinin, serotonin, and ventilatory hypoxia

Outcome

Pulmonary vasoconstrictor (pressor) responsessurrogate

ANG IV exhibits significant pulmonary vasoconstrictor activity mediated by AT1 receptors and modulated by AT2 receptors, prostaglandins, and nitric oxide in the rat lung.

Cite This Study

Nossaman et al. (1995) studied this question.

synapsesocial.com/papers/6a8d0ddeb78e02efa68e4e90 https://doi.org/10.1152/ajplung.1995.268.2.l302

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Analysis of responses to ANG IV: effects of PD-123319 and DuP-753 in the pulmonary circulation of the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Analysis of responses to ANG IV: effects of PD-123319 and DuP-753 in the pulmonary circulation of the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider