Population
Isolated perfused hydronephrotic rat kidneys (interlobular arteries)
Design
Preclinical
Authors
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Supports vessel size-dependent AT receptor distribution in rodent renal microvasculature; leaves open clinical translation to human kidney disease.
The distribution of angiotensin II receptor subtypes mediating vasoconstriction differs depending on the size of the renal microvasculature, with PD-123319-sensitive receptors participating more in larger segments.
Hayashi et al. (1993) studied this question.
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