Population
Isolated perfused hydronephrotic rat kidneys
Comparison
ANG-(1-7) and ANG IV vs ANG II
Design
Preclinical
Authors
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High-dose ANG-(1-7) and ANG IV may constrict renal microvessels via AT1 in rodents; leaves open net effects in human renal disease.
High concentrations of ANG-(1-7) and ANG IV induce renal microvascular constriction via the ANG II type 1 receptor, without exerting vasodilator or ANG II antagonistic actions.
Rodijnen et al. (2002) studied this question.
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