Key result
DuP 753 and its metabolite EXP3174 decreased lobar arterial pressure responses to angiotensin II in the pulmonary vascular bed of the intact-chest cat.
Why the study?
Do DuP 753 and EXP3174 inhibit pulmonary vascular responses to angiotensin II in an intact-chest cat model?
Population
Intact-chest cat model (pulmonary vascular bed)
Comparison
DuP 753 and its metabolite EXP3174 vs Baseline responses to angiotensin II and other…
Design
Preclinical
Authors
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Caution against clinical extrapolation from feline data; leaves open AT1 blockade effects on human pulmonary tone.
Do DuP 753 and EXP3174 inhibit pulmonary vascular responses to angiotensin II in an intact-chest cat model?
DuP 753 and its metabolite EXP3174 effectively inhibit angiotensin II-induced pulmonary vasoconstriction in a feline model, with differing competitive profiles based on dose.
McMahon et al. (1992) studied this question. DuP 753 and EXP3174 was evaluated on lobar arterial pressure response to angiotensin II. DuP 753 and its metabolite EXP3174 decreased lobar arterial pressure responses to angiotensin II in the pulmonary vascular bed of the intact-chest cat.
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