June 1, 1991British Journal of PharmacologyOpen Access

Cardiac haemodynamic effects of the non‐peptide, angiotensin II‐receptor antagonist, DuP 753, in conscious Long Evans and Brattleboro rats

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Population

Male Long Evans and Brattleboro rats, chronically instrumented. Groups: water-replete Long Evans…

Comparison

Incremental i.v. bolus doses of DuP 753… vs Baseline resting conditions prior to drug…

Design

Preclinical

Follow-up

Acute (15 min intervals between doses)

Authors

PBP D BatinUniversity of Belgrade SGSheila M. GardinerUniversity of Nottingham ACA.M. ComptonAlbert Einstein College of Medicine

Discussion

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Implication

Supports vasodilator action without myocardial depression in animals; leaves open translation to human cardiovascular therapy.

Structured PICO

Population

Male Long Evans and Brattleboro rats, chronically instrumented. Groups: water-replete Long Evans (n=8), water-replete Brattleboro (n=8), and water-deprived (14 h) Brattleboro rats (n=9).

Intervention

Incremental i.v. bolus doses (0.1-10 mg kg-1, at 15 min intervals) of DuP 753, followed by a supramaximal dose of captopril (2 mg kg-1) 15 min after the highest dose.

Comparator

Baseline resting conditions prior to drug administration.

Outcome

Cardiac haemodynamics including heart rate, mean arterial blood pressure, cardiac output, stroke volume, peak aortic flow, + dF/dtmax, total peripheral conductance, and central venous pressure.surrogate

The hypotensive effects of the angiotensin II-receptor antagonist DuP 753 are explained by its vasodilator action, without any negative effects on myocardial function.

Cite This Study

Batin et al. (1991) studied this question.

synapsesocial.com/papers/6a6fe964ce524a4339c3bcfd https://doi.org/10.1111/j.1476-5381.1991.tb09831.x

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Cardiac haemodynamic effects of the non‐peptide, angiotensin II‐receptor antagonist, DuP 753, in conscious Long Evans and Brattleboro rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac haemodynamic effects of the non‐peptide, angiotensin II‐receptor antagonist, DuP 753, in conscious Long Evans and Brattleboro rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider