Why the study?
Does central administration of the AT1 antagonist DuP 753 lower blood pressure in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (normal and furosemide-treated on low Na+ diet)
Comparison
Intracerebroventricular DuP 753 or oral DuP 753 vs Controls (absence of DuP 753)
Design
Preclinical
Follow-up
48 hours
Authors
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Supports peripheral AT1 mediation of DuP 753 effects in rats; leaves open central roles in other models or species.
Does central administration of the AT1 antagonist DuP 753 lower blood pressure in spontaneously hypertensive rats?
The antihypertensive effect of the AT1 antagonist DuP 753 in spontaneously hypertensive rats is mediated by peripheral, not central, AT1 receptors.
DePasquale et al. (1992) studied this question.
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