Why the study?
Does DuP 753 reduce blood pressure in spontaneously hypertensive rats?
Population
Conscious 18-21-week-old spontaneously hypertensive rats and Wistar-Kyoto normotensive rats
Comparison
DuP 753 given orally at 3 and 10 mg/kg or… vs Captopril, saralasin, and baseline
Design
Preclinical
Follow-up
Up to 24 hours
Authors
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Extends preclinical support for nonpeptide ARBs in hypertensive models; leaves open translation to human hypertension.
Does DuP 753 reduce blood pressure in spontaneously hypertensive rats?
DuP 753 is a nonpeptide angiotensin II receptor antagonist that effectively and durably reduces blood pressure in spontaneously hypertensive rats without causing a transient pressor effect.
Wong et al. (1990) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: