Population
Cultured rat C6 glioma, human astrocytoma, and porcine aortic smooth muscle cells
Comparison
DuP 753 at doses 10 M to 10 M, alone or in… vs Angiotensin II alone or basal conditions
Design
Preclinical
Authors
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Potential mechanism for ARB antihypertensive effects; leaves open confirmation in human studies.
The angiotensin II antagonist DuP 753 potently stimulates prostacyclin release in vascular smooth muscle cells, suggesting a potential mechanism contributing to its anti-hypertensive effects.
Jaiswal et al. (1991) studied this question.
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