April 1, 1991American Journal of Hypertension

In Vitro Pharmacology of DuP 753

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Population

In vitro models: rat adrenal cortical microsomes, cultured rat aortic smooth muscle cells, rabbit aortic…

Design

Preclinical

Authors

ACAndrew T. ChiuHong Kong Polytechnic University DMDale E. McCallDuPont (United States)WPWilliam A. PriceThe University of Texas Health Science Center at San Antonio

Discussion

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Implication

Supports DuP 753 as experimental tool for renin-angiotensin research; leaves open clinical translation in hypertension.

Structured PICO

Population

In vitro models: rat adrenal cortical microsomes, cultured rat aortic smooth muscle cells, rabbit aortic strips, rabbit lung converting enzyme, and rat/human renin.

Intervention

DuP 753 (2-n-butyl-4-chloro-5-hydroxymethyl-1-[2'-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl]imidazole, potassium salt)

Outcome

Affinity and specificity for functional antagonism of angiotensin II (AII) receptorssurrogate

DuP 753 is a highly potent and specific angiotensin II receptor antagonist in vitro, serving as a useful experimental tool for studying the renin-angiotensin system.

Cite This Study

Chiu et al. (1991) studied this question.

synapsesocial.com/papers/6a7d8616968fa26fcacb49c7 https://doi.org/10.1093/ajh/4.4.282s

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In Vitro Pharmacology of DuP 753

Discussion

Member takes

Implication

Structured PICO

Cite This Study

In Vitro Pharmacology of DuP 753

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider