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January 1, 1997Thrombosis and Haemostasis

Sensitive Measurement of Thrombopoietin by a Monoclonal Antibody Based Sandwich Enzyme-linked Immunosorbent Assay

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Population

193 controls and 5 thrombocytopenic patients

Design

Other

Authors

CFClaudia C. FolmanSanquinABA. E. G. Kr. von dem BorneDutch Blood Transfusion SocietyIRIrma RensinkSanquin

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Implication

Validates sensitive TPO ELISA for research; leaves clinical diagnostic adoption open pending prospective validation.

Structured PICO

P
Population
193 controls and 5 thrombocytopenic patients
I
Intervention
Monoclonal antibody-based sandwich enzyme-linked immunosorbent assay (ELISA) for plasma thrombopoietin (Tpo)
O
Outcome
Assay performance (variance, limit of detection, recovery) and Tpo concentrationssurrogate

The developed monoclonal antibody-based ELISA is a sensitive and reliable tool for measuring plasma thrombopoietin levels, suitable for large-scale studies.

Cite This Study

Folman et al. (1997) studied this question.

synapsesocial.com/papers/6a8a41960f137e402b337b4bhttps://doi.org/10.1055/s-0038-1657725
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders1996 · 207 citations
  2. 2Development of an Automated Chemiluminescent Enzyme Immunoassay for Measuring Thrombopoietin in Human Plasma2022 · 7 citations
  3. 3Thrombopoietin levels in patients with disorders of platelet production: Diagnostic potential and utility in predicting response to TPO Receptor agonists2013 · 94 citations
  4. 4The Diagnostic Value of Thrombopoietin Level Measurements in Thrombocytopenia1998 · 97 citations
  5. 5Plasma thrombopoietin levels as additional tool in clinical management of thrombocytopenic neonates2019 · 4 citations