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June 1, 1996British Journal of Haematology

A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders

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Key result

A sensitive sandwich ELISA for serum thrombopoietin demonstrated significantly higher TPO levels in patients with aplastic anaemia (18.53 fmol/ml) and ALL (10.36 fmol/ml) than normal individuals.

Population

68 individuals, including 50 healthy volunteers and 18 patients with haemopoietic disorders.

Comparison

Measurement of serum thrombopoietin using a… vs Healthy volunteers vs. patients with…

Design

Cross-sectional

Authors

TTTomoyuki TaharaKyowa Kirin (Japan)KUKensuke UsukiNTT Medical CenterHSHiroaki SatoUniversity of Occupational and Environmental Health Japan

Discussion

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Member takes

Overview

May support differential diagnosis of thrombocytopenia; leaves open whether TPO levels predict outcomes or guide therapy in aplastic anaemia and ALL.

Study Design

Type

Observational (n=68)

Structured PICO

P
Population
68 individuals, including 50 healthy volunteers (29 males, 21 females) and 18 patients with haemopoietic disorders (7 with aplastic anaemia, 5 with acute lymphocytic leukemia, 6 with essential thrombocythaemia).
I
Intervention
Measurement of serum thrombopoietin (TPO) using a newly developed sensitive sandwich ELISA.
C
Comparator
Healthy volunteers vs. patients with haemopoietic disorders.
O
Outcome
Serum thrombopoietin (TPO) concentration.surrogate

A newly developed sensitive sandwich ELISA can accurately measure serum thrombopoietin levels, which are significantly elevated in patients with aplastic anaemia, acute lymphocytic leukemia, and essential thrombocythaemia.

Cite This Study

Tahara et al. (1996) conducted an observational in Haemopoietic disorders (n=68). Sandwich ELISA for serum thrombopoietin vs. Healthy volunteers was evaluated on Serum thrombopoietin (TPO) concentration. A sensitive sandwich ELISA for serum thrombopoietin demonstrated significantly higher TPO levels in patients with aplastic anaemia (18.53 fmol/ml) and ALL (10.36 fmol/ml) than normal individuals.

synapsesocial.com/papers/6a0cf5cb4e02b7512ccc8e9ehttps://doi.org/10.1046/j.1365-2141.1996.d01-1741.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sensitive Measurement of Thrombopoietin by a Monoclonal Antibody Based Sandwich Enzyme-linked Immunosorbent Assay1997 · 63 citations
  2. 2Thrombopoietin levels in patients with disorders of platelet production: Diagnostic potential and utility in predicting response to TPO Receptor agonists2013 · 94 citations
  3. 3The Diagnostic Value of Thrombopoietin Level Measurements in Thrombocytopenia1998 · 97 citations
  4. 4Development of an Automated Chemiluminescent Enzyme Immunoassay for Measuring Thrombopoietin in Human Plasma2022 · 7 citations
  5. 5Age‐related changes in thrombopoietin in children: reference interval for serum thrombopoietin levels1999 · 62 citations