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September 1, 1999British Journal of Haematology

Age‐related changes in thrombopoietin in children: reference interval for serum thrombopoietin levels

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Population

254 disease-free children and adult volunteers

Design

Cross-sectional

Authors

AIAkira IshiguroNational Center For Child Health and DevelopmentTNTatsutoshi NakahataCentral Institute for Experimental AnimalsKMKousaku MatsubaraKobe City Nishi-Kobe Medical Center

Discussion

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Implication

Neonatal TPO reference ranges now defined; extends normative data but requires prospective validation before clinical use.

Structured PICO

P
Population
254 disease-free children and adult volunteers
O
Outcome
Serum thrombopoietin (TPO) levels across different age groupssurrogate

Serum thrombopoietin levels are highest in the first month of life and gradually decrease to adult levels, establishing a reference interval for children.

Cite This Study

Ishiguro et al. (1999) studied this question.

synapsesocial.com/papers/6a8a41be5c4c6b099dec8cdchttps://doi.org/10.1046/j.1365-2141.1999.01641.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders1996 · 207 citations
  2. 2The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit1995 · 397 citations
  3. 3Native thrombopoietin: Structure and function1998 · 47 citations
  4. 4Impaired Expression of the Thrombopoietin Receptor by Platelets from Patients with Polycythemia Vera1998 · 310 citations
  5. 5Thrombopoietin Concentration in Umbilical Cord Blood of Healthy Term Newborns Is Higher than in Adult Controls1998 · 37 citations