Why the study?
Does diuretic therapy reduce urinary N-acetyl-beta-glucosaminidase (NAG) levels in patients with essential hypertension?
Population
80 subjects with essential hypertension (and no evidence of renal disease) and 30 normal controls.
Comparison
Diuretics for 12 months vs Baseline values and 30 normal controls
Design
Cohort
Follow-up
1 year
Authors
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NAG reduction with diuretics supports its role as early marker of hypertensive renal injury; hypothesis-generating and should not yet change practice.
Does diuretic therapy reduce urinary N-acetyl-beta-glucosaminidase (NAG) levels in patients with essential hypertension?
Urinary NAG is elevated in essential hypertension without overt renal disease and can be reduced by successful antihypertensive therapy, suggesting its potential as an early marker of hypertensive renal injury.
Alderman et al. (1983) studied this question.
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