April 1, 2003British Journal of PharmacologyOpen Access

Endothelin as a causative factor of blunted volume reflex in diabetic rats

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Population

Nondiabetic and streptozotocin-induced diabetic rats

Comparison

Acute isotonic saline volume expansion in the… vs Acute isotonic saline volume expansion in the…

Design

Preclinical

Follow-up

acute

Authors

OWOrawan WongmekiatChiang Mai University EJEdward J. JohnsUniversity College Cork

Discussion

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Implication

ET(B) activation may impair natriuresis in diabetic models; leaves open whether antagonism improves sodium handling in human diabetic kidney disease.

Structured PICO

Population

Nondiabetic and streptozotocin-induced diabetic rats

Intervention

Acute isotonic saline volume expansion (10% body wt) in the presence of endothelin antagonists (nonselective ET(A)/ET(B) antagonist SB209670 or selective ET(A) antagonist)

Comparator

Acute isotonic saline volume expansion in the absence of endothelin antagonists

Outcome

Cumulative urine sodium excretion (CuU(Na)V) after volume expansionsurrogate

Activation of ET(B) receptors contributes to the depressed ability to excrete a saline load in diabetes mellitus, though its impact is obscured by the influence of renal nerves.

Cite This Study

Wongmekiat et al. (2003) studied this question.

synapsesocial.com/papers/6a8a43aa439f8b7e014346b6 https://doi.org/10.1038/sj.bjp.0705133

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Implication

ET(B) activation may impair natriuresis in diabetic models; leaves open whether antagonism improves sodium handling in human diabetic kidney disease.

Endothelin as a causative factor of blunted volume reflex in diabetic rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelin as a causative factor of blunted volume reflex in diabetic rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider