August 1, 1994AJP Regulatory Integrative and Comparative Physiology

Reduced renal sympathoinhibition in response to acute volume expansion in diabetic rats

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Population

Anesthetized Sprague-Dawley rats, including control rats, streptozotocin-induced diabetic rats, and diabetic…

Comparison

Acute graded volume expansion with isotonic… vs Control rats and untreated diabetic rats.

Design

Preclinical

Authors

KPKaushik P. PatelHeart Failure & Transplant PZP. L. ZhangUniversity of Nebraska Medical Center

Discussion

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Implication

Blunted volume regulation in diabetic rats may contribute to fluid retention; leaves open whether insulin restores these responses in patients.

Structured PICO

Population

Anesthetized (Inactin; 0.1 g/kg ip) Sprague-Dawley rats, including control rats (vehicle; n=7), streptozotocin (STZ)-induced diabetic rats (STZ 65 mg/kg ip 2 wk before experiment; n=7), and diabetic rats treated with insulin (n=6) or enalapril.

Intervention

Acute graded volume expansion (VE) with isotonic saline, evaluated after treatments including insulin (2 U/day sc for 2 wk), acute insulin, or enalapril (10 mg/day by mouth for 2 wk).

Comparator

Control rats (vehicle) and untreated diabetic rats.

Outcome

Renal sympathoinhibition, urine flow, and sodium excretion in response to acute volume expansion.surrogate

In a diabetic rat model, acute volume expansion-induced renal sympathoinhibition and excretory responses are blunted, which can be reversed by chronic insulin therapy but not by enalapril.

Cite This Study

Patel et al. (1994) studied this question.

synapsesocial.com/papers/6a8a3eaf5edafe343d930b85 https://doi.org/10.1152/ajpregu.1994.267.2.r372

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Implication

Blunted volume regulation in diabetic rats may contribute to fluid retention; leaves open whether insulin restores these responses in patients.

Reduced renal sympathoinhibition in response to acute volume expansion in diabetic rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reduced renal sympathoinhibition in response to acute volume expansion in diabetic rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider