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October 1, 2003The Journal of Physiology

L-type Ca2+ channels serve as a sensor of the SR Ca2+ for tuning the efficacy of Ca2+-induced Ca2+ release in rat ventricular myocytes

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Population

Rat ventricular myocytes

Comparison

Depletion of sarcoplasmic reticulum Ca2+ with… vs SR-intact myocytes

Design

Preclinical

Authors

HTHajime TakamatsuAstellas Pharma (Japan)TNTaku NagaoNational Institute of Health SciencesHIHidenori IchijoInstitute for Advanced Medical Research

Discussion

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Implication

Hypothesis-generating in isolated myocytes; leaves open CICR-dependent CDI's role in human SR Ca2+ regulation and arrhythmias.

Structured PICO

P
Population
Rat ventricular myocytes
I
Intervention
Depletion of sarcoplasmic reticulum (SR) Ca2+ with thapsigargin or caffeine to eliminate CICR-dependent Ca2+-dependent inactivation (CDI)
C
Comparator
SR-intact myocytes
O
Outcome
Action potential duration (APD) and amount of Ca2+-influx through Ca2+ channels during action potentialsurrogate

CICR-dependent CDI of L-type Ca2+ channels plays an important role in monitoring and tuning SR Ca2+ content by modulating action potential waveform and Ca2+ influx in ventricular myocytes.

Cite This Study

Takamatsu et al. (2003) studied this question.

synapsesocial.com/papers/6a8a46b6176d2ac34cfbcf89https://doi.org/10.1111/j.1469-7793.2003.00415.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cross-signaling between L-type Ca2+ channels and ryanodine receptors in rat ventricular myocytes.1996 · 187 citations
  2. 2Alterations in action potential profile enhance excitation‐contraction coupling in rat cardiac myocytes2001 · 82 citations
  3. 3Ca <sup>2+</sup> Influx During the Cardiac Action Potential in Guinea Pig Ventricular Myocytes1996 · 130 citations
  4. 4Control of L‐type calcium current during the action potential of guinea‐pig ventricular myocytes1998 · 109 citations
  5. 5Effects of Action Potential Duration on Excitation-Contraction Coupling in Rat Ventricular Myocytes1995 · 217 citations