Why the study?
What are the effects of temperature, shear rate, hematocrit, and different volume expanders on blood viscosity in conditions mimicking deep hypothermia?
Population
Blood obtained from six healthy adults
Comparison
Dilutions to hematocrits of 35%, 30%, 22.5%, and… vs Different temperatures, hematocrits, and diluents
Design
Preclinical
Authors
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Moderate hemodilution lowers viscosity at 15°C in animal models; leaves open any clinical benefit during deep hypothermic cardiac surgery.
What are the effects of temperature, shear rate, hematocrit, and different volume expanders on blood viscosity in conditions mimicking deep hypothermia?
Moderate hemodilution to a hematocrit of 22% significantly decreases blood viscosity at low temperatures, potentially improving microcirculatory perfusion during deep hypothermia for cardiac operations.
Eckmann et al. (2000) studied this question.
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