November 1, 1999The Journal of Clinical Endocrinology & MetabolismOpen Access

Effect of Severe Growth Hormone (GH) Deficiency due to a Mutation in the GH-Releasing Hormone Receptor on Insulin-Like Growth Factors (IGFs), IGF-Binding Proteins, and Ternary Complex Formation Throughout Life1

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Population

82 subjects, comprising 27 with severe growth hormone deficiency due to an identical GHRH receptor mutation…

Design

Case-control

Authors

MAManuel H. Aguiar‐OliveiraUniversidade Federal de Sergipe MGMatthew S. GillUniversity of Minnesota EDElenilde S. deUniversidade Federal de Sergipe

Discussion

Member takes

Implication

May support age-tailored IGF-I ternary complex or ALS testing in GHD; leaves open prospective validation before diagnostic adoption.

Structured PICO

Population

82 subjects, comprising 27 with severe growth hormone deficiency (GHD) due to an identical GHRH receptor mutation (aged 5-82 yr) from an extended kindred, and 55 indigenous controls (aged 5-80 yr).

Comparator

55 indigenous controls (aged 5-80 yr)

Outcome

Concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3, and acid labile subunit (ALS), and the theoretical distribution of IGFs between the IGFBPs and the ternary complexsurrogate

Severe GHD modifies the distribution of IGFs bound to each IGFBP, and diagnostic tests like IGF-I in the ternary complex or free ALS should be tailored to the patient's age.

Cite This Study

Aguiar‐Oliveira et al. (1999) studied this question.

synapsesocial.com/papers/6a8a4dce186271ac99335cde https://doi.org/10.1210/jcem.84.11.6133

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Effect of Severe Growth Hormone (GH) Deficiency due to a Mutation in the GH-Releasing Hormone Receptor on Insulin-Like Growth Factors (IGFs), IGF-Binding Proteins, and Ternary Complex Formation Throughout Life1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of Severe Growth Hormone (GH) Deficiency due to a Mutation in the GH-Releasing Hormone Receptor on Insulin-Like Growth Factors (IGFs), IGF-Binding Proteins, and Ternary Complex Formation Throughout Life1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider