Key result
IGF-I and IGFBP-3 serum concentrations predict the outcome of a GH provocative test in young adults with childhood-onset disease, identifying 45% of isolated GHD patients with a normal GH response.
Why the study?
Do IGF-I and IGFBP-3 levels predict the outcome of a GH provocative test in young adults with childhood-onset GH deficiency?
Population
108 young adults who had previously been treated with GH during childhood for GH deficiency, and 1237…
Comparison
GH provocative test using oral clonidine, and… vs Healthy controls and peak GH levels
Design
Cross-sectional
Authors
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IGF-I and IGFBP-3 serum concentrations are valuable diagnostic parameters in evaluating GH deficiency in adults with childhood-onset disease, and retesting is recommended unless multiple pituitary hormone deficiencies are present.
Cross-Sectional (n=108)
Do IGF-I and IGFBP-3 levels predict the outcome of a GH provocative test in young adults with childhood-onset GH deficiency?
IGF-I and IGFBP-3 serum concentrations are valuable diagnostic parameters in evaluating GH deficiency in adults with childhood-onset disease, and retesting is recommended unless multiple pituitary hormone deficiencies are present.
Juul et al. (1997) conducted a cross-sectional in Childhood-onset growth hormone deficiency (n=108). IGF-I and IGFBP-3 serum concentrations vs. Peak GH levels (provocative test) was evaluated on Peak GH values below a cut-off of 7.5 micrograms/L. IGF-I and IGFBP-3 serum concentrations predict the outcome of a GH provocative test in young adults with childhood-onset disease, identifying 45% of isolated GHD patients with a normal GH response.
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