March 1, 1977Archives of Disease in ChildhoodOpen Access

Aetiology of idiopathic growth hormone deficiency in England and Wales.

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Population

208 cases of idiopathic growth hormone deficiency from England and Wales treated under the Medical Research…

Design

Cohort

Authors

RRRoberto J. RonaKing's College London JTJ. M. TannerCambridge University Hospitals NHS Foundation Trust

Discussion

Member takes

Implication

Perinatal factors were associated with idiopathic GHD; hypothesis-generating and should not yet change practice or inform prevention.

Structured PICO

Population

208 cases of idiopathic growth hormone deficiency (140 with detailed information on relatives, 68 further cases) from England and Wales treated under the Medical Research Council Clinical Trial of Human Growth Hormone up till 1974.

Comparator

Perinatal Mortality survey of 1958

Outcome

Incidence of birth complications (breech births, forceps deliveries, early vaginal bleeding) and family history of growth hormone deficiency

Idiopathic growth hormone deficiency appears to have a multifactorial aetiology involving both polygenic inheritance and environmental factors such as birth trauma.

Cite This Study

Rona et al. (1977) studied this question.

synapsesocial.com/papers/6a8a4e31a90c2f4c44fbb6d9 https://doi.org/10.1136/adc.52.3.197

View Full Paper

Ask AI

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Aetiology of idiopathic growth hormone deficiency in England and Wales.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Aetiology of idiopathic growth hormone deficiency in England and Wales.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider