Population
Left ventricular myocytes isolated from nontransgenic control and transgenic mice overexpressing either beta…
Comparison
Acute beta 1-AR stimulation with five… vs Comparison among NTG, TG beta K12, and TGMini27…
Design
Preclinical
Authors
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Beta ARK1 modulation of beta1-AR desensitization may alter myocyte contractility; leaves open therapeutic targeting in heart failure models.
Beta ARK1 plays a critical role in the agonist-induced desensitization of cardiac beta 1-adrenergic receptors, significantly modulating the contractile response of single myocytes.
Korzick et al. (1997) studied this question.
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