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July 1, 1990Journal of Clinical MicrobiologyOpen Access

Laboratory identification of adenoviruses associated with gastroenteritis in Canada from 1983 to 1986

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Population

143 stool specimens collected between 1983 and 1986 from symptomatic patients with gastroenteritis whose…

Comparison

DNA restriction analysis vs Serum neutralization

Design

Cross-sectional

Authors

MBMartha BrownUniversity of Toronto

Discussion

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Overview

May support DNA restriction analysis for enteric adenovirus typing in research; leaves clinical adoption open pending prospective validation.

Structured PICO

P
Population
143 stool specimens collected between 1983 and 1986 from symptomatic patients with gastroenteritis whose stools were positive for adenovirus by electron microscopy
I
Intervention
DNA restriction analysis (SmaI and HindIII cleavage)
C
Comparator
Serum neutralization
O
Outcome
Identification of adenovirus serotypes

DNA restriction analysis is superior to serum neutralization for identifying enteric adenovirus serotypes in stool specimens.

Cite This Study

Martha Brown (1990) studied this question.

synapsesocial.com/papers/6a8a50861acf8e321fbd78b0https://doi.org/10.1128/jcm.28.7.1525-1529.1990
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genome variants of adenovirus 41 (subgroup G) from children with diarrhoea in South Africa1984 · 61 citations
  2. 2Evaluation of a commercial monoclonal antibody-based enzyme immunoassay for detection of adenovirus types 40 and 41 in stool specimens1989 · 42 citations
  3. 3Selection of nonfastidious adenovirus species in 293 cells inoculated with stool specimens containing adenovirus 401985 · 40 citations
  4. 4Faecal adenoviruses from Glasgow babies Studies on culture and identity1982 · 54 citations
  5. 5Evaluation of a commercial monoclonal antibody for detection of adenovirus antigen1987 · 37 citations