Why the study?
Are 293 cells more sensitive than HeLa cells for the isolation of enteric adenoviruses from stool specimens?
Population
35 stool specimens from pediatric gastroenteritis patients shown to contain adenovirus by electron microscopy
Comparison
Inoculation onto 293 cells vs Inoculation onto HeLa cells
Design
Preclinical
Authors
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May improve enteric adenovirus detection in labs; leaves open prospective validation before routine diagnostic use.
Are 293 cells more sensitive than HeLa cells for the isolation of enteric adenoviruses from stool specimens?
293 cells are more sensitive than HeLa cells for isolating enteric adenoviruses, and minimal passage is required to avoid misdiagnosis.
Brown et al. (1984) studied this question.
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