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February 1, 1987Journal of Medical Virology

Detection of adenovirus types 40 and 41 in stool specimens by immune electron microscopy

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Why the study?

Does an immune electron microscope test accurately detect adenovirus types 40 and 41 in stool specimens from children with gastroenteritis compared to reference methods?

Population

72 stool specimens from children with gastroenteritis found to contain adenovirus by conventional electron…

Comparison

Immune electron microscope test using polyclonal… vs Reference methods

Design

Cross-sectional

Follow-up

13 months (study duration)

Authors

DWDavid J. WoodUniversity of LeedsABA. S. BaileyRensselaer Polytechnic Institute

Discussion

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Overview

May support rapid IEM use for adenovirus detection in pediatric gastroenteritis; leaves open routine adoption pending prospective validation.

Structured PICO

Does an immune electron microscope test accurately detect adenovirus types 40 and 41 in stool specimens from children with gastroenteritis compared to reference methods?

P
Population
72 stool specimens from children with gastroenteritis found to contain adenovirus by conventional electron microscope screening
I
Intervention
Immune electron microscope (IEM) test using polyclonal rabbit antisera
C
Comparator
Reference methods (conventional virus isolation and restriction endonuclease analysis)
O
Outcome
Diagnostic accuracy (sensitivity and specificity) for detecting adenovirus types 40 and 41surrogate

IEM is a rapid, highly sensitive, and specific method for detecting adenovirus types 40 and 41 in stool specimens.

Cite This Study

Wood et al. (1987) studied this question.

synapsesocial.com/papers/6a8a514e2e8050e6742e50a5https://doi.org/10.1002/jmv.1890210211
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnosis of fastidious enteric adenoviruses 40 and 41 in stool specimens1984 · 75 citations
  2. 2Detection of enteric adenoviruses by dot‐blot hybridization using a molecularly cloned viral DNA probe1985 · 39 citations
  3. 3Antibodies to fastidious faecal adenoviruses (species 40 and 41) in sera from children1983 · 63 citations
  4. 4Specific detection and typing of adenovirus types 40 and 41 in stool specimens by dot-blot hybridization1985 · 42 citations
  5. 5Enzyme‐linked immunosorbent assay for detection of enteric adenovirus 411985 · 40 citations