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June 1, 1989Journal of Clinical MicrobiologyOpen Access

Evaluation of a commercial monoclonal antibody-based enzyme immunoassay for detection of adenovirus types 40 and 41 in stool specimens

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Why the study?

Does a commercial monoclonal antibody-based enzyme immunoassay accurately detect adenovirus types 40 and 41 in stool specimens compared to immune electron microscopy?

Population

177 stool samples screened for the presence of adenovirus type 40 or 41

Comparison

Commercial monoclonal antibody-based enzyme… vs Polyclonal antibody-based immune electron…

Design

Other

Authors

DWDavid J. WoodUniversity of LeedsKBK BijlsmaJJJ.C. de JongLeiden University

Discussion

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Overview

May aid adenovirus gastroenteritis diagnosis in labs; leaves open need for validation versus modern reference standards.

Structured PICO

Does a commercial monoclonal antibody-based enzyme immunoassay accurately detect adenovirus types 40 and 41 in stool specimens compared to immune electron microscopy?

P
Population
177 stool samples screened for the presence of adenovirus type 40 or 41
I
Intervention
Commercial monoclonal antibody-based enzyme immunoassay (Adenoscreen)
C
Comparator
Polyclonal antibody-based immune electron microscope test
O
Outcome
Detection of adenovirus types 40 and 41 (sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy)surrogate

The Adenoscreen enzyme immunoassay provides excellent sensitivity and specificity for detecting adenovirus types 40 and 41 in stool specimens, aiding in the accurate diagnosis of adenovirus gastroenteritis.

Cite This Study

Wood et al. (1989) studied this question.

synapsesocial.com/papers/6a9511bb6a42edee3f2c97d1https://doi.org/10.1128/jcm.27.6.1155-1158.1989
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Detection of adenovirus types 40 and 41 in stool specimens by immune electron microscopy1987 · 27 citations
  2. 2Antigen Detection with Monoclonal Antibodies for the Diagnosis of Adenovirus Gastroenteritis1987 · 64 citations
  3. 3Recent Respiratory and Enteric Adenovirus Infection in Children in the Manchester Area1988 · 14 citations
  4. 4Enzyme‐linked immunosorbent assay for detection of enteric adenovirus 411985 · 41 citations
  5. 5Development and application of monoclonal antibodies for specific detection of human enteric adenoviruses1986 · 28 citations