What question did this study set out to answer?

Quantify the incidence, hospitalization rate, and in-hospital case fatality ratio of respiratory syncytial virus-related acute respiratory infections in adults with chronic comorbidities.

March 2, 2021The Journal of Infectious DiseasesOpen Access

Disease Burden Estimates of Respiratory Syncytial Virus related Acute Respiratory Infections in Adults With Comorbidity: A Systematic Review and Meta-Analysis

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Authors

TSTing ShiGuangzhou University of Chinese Medicine SVSophie VennardRoyal Hospital for Children FJFrancis JasiewiczThe Christie NHS Foundation Trust

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Implication

Systematic review and meta-analysis reveals a high respiratory syncytial virus burden in adults with comorbidities, highlighting the need for targeted preventative interventions.

Key Points

Quantify the incidence, hospitalization rate, and in-hospital case fatality ratio of respiratory syncytial virus-related acute respiratory infections in adults with chronic comorbidities.
Conducted a systematic review of studies published between January 1996 and March 2020 on RSV-related acute respiratory infections in adults with comorbid conditions.
Synthesized disease incidence, hospital outcomes, and association estimates across 20 included studies using random-effects meta-analyses.
Annual incidence rate of RSV-ARI in adults with comorbidities in industrialized countries was 37.6 per 1,000 persons per year (95% CI, 20.1–70.3), with a seasonal incidence rate of 28.4 per 1,000 persons (95% CI, 11.4–70.9).
In-hospital case fatality ratio in industrialized countries reached 11.7% (95% CI, 5.8%–23.4%), while data from developing countries and hospitalization meta-estimates were entirely lacking.
Odds of experiencing RSV-ARI were significantly elevated in univariable analyses comparing adults with versus without comorbidity (OR 4.1; 95% CI, 1.6–10.4), but attenuated in multivariable analyses (OR 1.1; 95% CI, 0.6–1.8).

Cite This Study

Shi et al. (2021) studied this question.

synapsesocial.com/papers/6a8a50894de818ad79d45317 https://doi.org/10.1093/infdis/jiab040

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Implication

Systematic review and meta-analysis reveals a high respiratory syncytial virus burden in adults with comorbidities, highlighting the need for targeted preventative interventions.

Disease Burden Estimates of Respiratory Syncytial Virus related Acute Respiratory Infections in Adults With Comorbidity: A Systematic Review and Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Disease Burden Estimates of Respiratory Syncytial Virus related Acute Respiratory Infections in Adults With Comorbidity: A Systematic Review and Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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