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August 13, 2009Journal of Clinical MicrobiologyOpen Access

Genomic Analyses of Recombinant Adenovirus Type 11a in China

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Population

Human adenovirus type 11 (HAdV-11) strain QS isolated in China

Comparison

Whole-genome sequencing and sequence comparison vs Sequences of strains within the species of HAdVs

Design

Preclinical

Authors

ZYZhaohui YangHainan Provincial Academy of Agricultural SciencesZZZhen ZhuNebraska Medical CenterLWLi WangUniversity of California, San Francisco

Discussion

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Implication

Alerts clinicians to recombinant adenovirus surveillance in respiratory disease; hypothesis-generating for human virulence impact.

Structured PICO

P
Population
Human adenovirus type 11 (HAdV-11) strain QS isolated in China
I
Intervention
Whole-genome sequencing and sequence comparison
C
Comparator
Sequences of strains within the species of HAdVs (e.g., HAdV-11a, HAdV-14)
O
Outcome
Genomic sequence, functional protein coding, and homology

Genomic analysis reveals that the HAdV-11 strain QS isolated in China is a recombinant adenovirus of HAdV-14, which may have implications for virulence in acute respiratory diseases.

Limitations

  • Difficult to clarify the time and manner of the recombination

Cite This Study

Yang et al. (2009) studied this question.

synapsesocial.com/papers/6a8a50d74e1caf75feec6402https://doi.org/10.1128/jcm.00282-09
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic Relationship between Thirteen Genome Types of Adenovirus 11, 34, and 35 with Different Tropisms1991 · 53 citations
  2. 2First Molecular Evidence for the Existence of Distinct Fish and Snake Adenoviruses2002 · 132 citations
  3. 3The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine1991 · 363 citations
  4. 4Update on adenovirus and its vectors2000 · 595 citations
  5. 5Severe Pneumonia Due to Adenovirus Serotype 14: A New Respiratory Threat?2008 · 132 citations