The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family
Population
HEK293 cells and guinea-pig cardiomyocytes
Comparison
Expression of Nedd4-2 or a catalytically… vs Endogenous Nedd4-2 or control conditions
Design
Preclinical
Authors
Discussion
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Implication
No immediate clinical implications for arrhythmia therapy; leaves open Nedd4-2 as a target for future translational studies.
Structured PICO
P
Population
HEK293 cells and guinea-pig cardiomyocytes
I
Intervention
Expression of Nedd4-2 or a catalytically inactive form of Nedd4-2
C
Comparator
Endogenous Nedd4-2 or control conditions
O
Outcome
KCNQ1 and KCNQ1/KCNE1 currents (I(Ks)) and KCNQ1 protein ubiquitylation/total levelssurrogate
The KCNQ1 potassium channel, which forms the delayed rectifier current I(Ks) in the heart, is physiologically regulated by Nedd4/Nedd4-like-dependent ubiquitylation, controlling its surface density.
Cite This Study
Jespersen et al. (2007) studied this question.