Modulation of Kv4-encoded K+ Currents in the Mammalian Myocardium by Neuronal Calcium Sensor-1

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Population

Adult mouse ventricles and HEK-293 cells

Comparison

Co-expression of neuronal calcium sensor… vs Kv4 alpha-subunits expressed alone

Design

Preclinical

Authors

Discussion

NCS-1 may modulate ventricular Ito,f; extends accessory-subunit biology of Kv4 channels but leaves open human arrhythmia relevance.

Population

Adult mouse ventricles and HEK-293 cells

Intervention

Co-expression of neuronal calcium sensor protein-1 (NCS-1) with Kv4 alpha-subunits

Comparator

Kv4 alpha-subunits expressed alone

Outcome

Membrane expression of Kv4 alpha-subunits, functional Kv4-encoded K(+) current densities, and rate of inactivationsurrogate

NCS-1 acts as an accessory subunit of Kv4-encoded I(to,f) channels, regulating their density and inactivation rate in the mammalian myocardium.

Guo et al. (2002) studied this question.

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