May 31, 2008Journal of NeurochemistryOpen Access

Altered phosphorylation and localization of the A‐type channel, Kv4.2 in status epilepticus

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Population

Rat kainate model of status epilepticus

Design

Preclinical

Authors

JLJoaquín N. LugoBaylor University LBLyndon Forbes BarnwellBaylor College of Medicine YRYajun RenNanjing Agricultural University

Discussion

Member takes

Implication

May link ERK to Kv4.2 trafficking in seizures; hypothesis-generating for excitability targets in epilepsy models.

Structured PICO

Population

Rat kainate model of status epilepticus (hippocampal whole cell, membrane, synaptosomal, and surface biotinylated extracts)

Intervention

Systemic kainate

Outcome

ERK activation, Kv4.2 phosphorylation, and Kv4.2 levels/localizationsurrogate

In a rat model of status epilepticus, ERK pathway activation couples to Kv4.2 phosphorylation and decreases its surface expression, suggesting a mechanism for altered intrinsic membrane excitability.

Cite This Study

Lugo et al. (2008) studied this question.

synapsesocial.com/papers/6a8a596be7982ec3bdde8586 https://doi.org/10.1111/j.1471-4159.2008.05508.x

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Altered phosphorylation and localization of the A‐type channel, Kv4.2 in status epilepticus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Altered phosphorylation and localization of the A‐type channel, Kv4.2 in status epilepticus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider