Why the study?
Do intravenous coronary vasodilators suppress ventricular arrhythmias in canine models?
Population
canine ventricular arrhythmia models (halothane-adrenaline arrhythmia and digitalis arrhythmia)
Design
Preclinical
Authors
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Hypothesis-generating for model-specific effects of calcium antagonists; no clinical implications from this animal study.
Do intravenous coronary vasodilators suppress ventricular arrhythmias in canine models?
Certain coronary vasodilators like verapamil and diltiazem suppress halothane-adrenaline-induced, but not digitalis-induced, ventricular arrhythmias in canine models, likely via calcium channel blockade.
Komori et al. (1985) studied this question.
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