Why the study?
Does timely primary PCI improve myocardial salvage and lower mortality compared to fibrinolytic therapy in STEMI patients?
Does timely primary PCI improve myocardial salvage and lower mortality compared to fibrinolytic therapy in STEMI patients?
Timely primary PCI remains the preferred therapy for STEMI, with its superiority over fibrinolytic therapy diminishing if delayed beyond approximately 2 hours.
Timely primary percutaneous coronary intervention (PCI) is the preferred therapy for ST-segment elevation myocardial infarction (STEMI).1 The challenge, however, lies in the definition of “timely.” In general, the shorter the time from symptom onset to PCI is, the higher the likelihood of myocardial salvage and lower associated mortality. Studies suggest that the tipping point for when primary PCI is no longer superior to fibrinolytic therapy is approximately 2 hours, though the exact time depends on the duration of ischemia, the amount of myocardium in jeopardy, and the bleeding risk of the patient, among other factors.2,3 In industrialized urban settings, . . .
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Deepak L. Bhatt (2013) studied this question.
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