April 11, 2003European Journal of Biochemistry

No evidence for a role in signal‐transduction of Na+/K+‐ATPase interaction with putative endogenous ouabain

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Population

Rat cardiac myocytes and renal cells

Design

Review

Authors

OHOtto HansenLund University

Discussion

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Implication

Challenges endogenous ouabain as physiological Na+/K+-ATPase signal; leaves open alternative mediators at measured plasma levels.

Structured PICO

Population

Rat cardiac myocytes and renal cells

Intervention

Ouabain

Outcome

Signal transduction cascade (intracellular Na+ and Ca2+ concentrations)

The hypothesis that endogenous ouabain acts as a physiological inducer of the Na+/K+-ATPase signaling system is challenged by the requirement for non-physiological, high concentrations of ouabain to initiate the cascade.

Cite This Study

Otto Hansen (2003) studied this question.

synapsesocial.com/papers/6a8a5def06e1858e55de87e7 https://doi.org/10.1046/j.1432-1033.2003.03554.x

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No evidence for a role in signal‐transduction of Na+/K+‐ATPase interaction with putative endogenous ouabain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

No evidence for a role in signal‐transduction of Na+/K+‐ATPase interaction with putative endogenous ouabain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider