January 1, 1991Japanese Circulation Journal-english EditionOpen Access

Anticoagulant Heparin-like Glycosaminoglycans on Endothelial Cell Surface.

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Population

Endothelial cell cultures

Design

Preclinical

Authors

KSKazuyuki ShimadaNihon University MKMasashi KobayashiObayashi (Japan)SKShigeaki KimuraUniversity of Fukui

Discussion

Member takes

Implication

Animal data link endothelial heparan sulfate disruption to reduced anticoagulation; leaves open relevance to human thrombosis or atherogenesis.

Structured PICO

Population

Endothelial cell cultures

Intervention

beta-D-xyloside or cytokine treatments

Outcome

Anti-thrombin III binding and heparin-like anticoagulant activitysurrogate

Heparan sulfate on the endothelial cell surface exerts heparin-like anticoagulant activity that can be modulated by cytokines or beta-D-xyloside, with potential implications for thrombosis and atherogenesis.

Cite This Study

Shimada et al. (1991) studied this question.

synapsesocial.com/papers/6a8a5e5d5c4c6b099dec923b https://doi.org/10.1253/jcj.55.1016

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Implication

Animal data link endothelial heparan sulfate disruption to reduced anticoagulation; leaves open relevance to human thrombosis or atherogenesis.

Anticoagulant Heparin-like Glycosaminoglycans on Endothelial Cell Surface.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Anticoagulant Heparin-like Glycosaminoglycans on Endothelial Cell Surface.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider