Key result
Heparin sulphate prevented platelet adhesion to collagen, but specific removal of endogenous heparin sulphate did not affect the binding of platelets to endothelial cells.
Heparin sulphate prevents platelet adhesion to collagen, though removing endogenous HS from endothelial cells does not affect platelet binding.
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Heparan sulfate's inhibition of platelet-collagen adhesion is hypothesis-generating; leaves open any endothelial protective role and precludes clinical translation.
Vascular endothelial cells (EC) are non-thrombogenic. The basis for this property is still essentially unknown. This paper summarizes our previous studies on EC associated glycosaminoglycans and on the specific binding of heparin to EC and describes the preventive effect of heparin sulphate (HS) on platelet adhesion to collagen; attempts to affect the binding of platelets to EC by specific removal of endogenous HS were, however, unsuccessful. The possible importance of EC surface HS for interactions with coagulation factors is discussed.
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Busch et al. (2009) conducted a review in Endothelial cell properties. Heparin sulphate was evaluated on Platelet adhesion to collagen and binding to endothelial cells. Heparin sulphate prevented platelet adhesion to collagen, but specific removal of endogenous heparin sulphate did not affect the binding of platelets to endothelial cells.
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