A significant proportion of eligible patients with diabetes and/or chronic kidney disease in general practice are not prescribed guideline-directed ACE inhibitor or ARB therapy.
Indicates possible undertreatment of diabetes and CKD with ACE/ARB in general practice; hypothesis-generating and requires prospective confirmation before informing care.
OBJECTIVE: To examine electronic records of GP management of chronic kidney disease. DESIGN: Cross-sectional study. SETTING: Thirteen general practices. PARTICIPANTS: Fifteen thousand four hundred and fiftteen active patients aged 50 years and over. MAIN OUTCOME MEASURE: Recorded estimated glomerular filtration rate (eGFR) and diabetes, and rate of prescribing of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ACE/ARBs). RESULTS: Six thousand and fifty-nine (39%) patients had hypertension and 1859 (12%), diabetes. Two thousand six hundred and eighty-nine (17%) patients were recorded with eGFR < 60 mL min(-1) (1.73 m(2) )(-1) , while 3344 (22%) did not have an eGFR result recorded. Hypertension, diabetes and eGFR <60 mL min(-1) (1.73 m(2) )(-1 ) were shown to be significantly related to prescribing of ACE/ARBs; however, 31% of known diabetics and 23% of diabetics with an eGFR < 60 mL min(-1) (1.73 m(2) )(-1 ) are not recorded as receiving ACE or ARB therapy. Forty-two per cent of patients with eGFR < 60 mL min(-1) (1.73 m(2) )(-1) , are also not recorded as receiving ACE or ARB therapy. There was a 23% variation in the rates of prescribing of ACE/ARBs by practice for patients with diabetes and eGFR < 60 mL min(-1) (1.73 m(2) )(-1) . CONCLUSION: The overall recording of eGFR and the recorded prescribing of ACE or ARB therapy in known diabetics and patients with eGFR < 60 mL min(-1) (1.73 m(2) )(-1) appear suboptimal. Also, the variations in prescribing between practices require further investigation.
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Pilotto et al. (2012) studied this question.
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