Early stages of diabetes (4 weeks) in rat models decrease the vasopressor response to norepinephrine and dopamine, contrasting with increased vasoconstriction seen in advanced stages.
Answers are grounded in this paper and cite their sources.
Should not change clinical vasopressor dosing; leaves open whether early diabetes hyporesponsiveness occurs in humans.
Diabetes has been related to changes in vascular responses, mainly an increase in the vasoconstrictor responses and a decrease in the vasodilator responses. The literature has now begun to study the effects of diabetes in the early stages of development; the first studies on these stages indicate that diabetes produces different changes compared to the advanced stages. For that reason, the aim of this work was to evaluate the responses to norepinephrine and dopamine on normotensive and hypertensive rats with 4 weeks of diabetes evolution. The results showed that 4 weeks of diabetes produces a decrease of the vasopressor response to both agents (norepinephrine and dopamine). These results suggest that in the early stages, there are changes that help to decrease the pressor responses and these changes could disappear in the advanced stages.
No takes yet. Share an insight, caveat, or question.
Hong et al. (2010) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: