Why the study?
Does aerosol NOS2 gene transfer reduce hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats?
Does aerosol NOS2 gene transfer reduce hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats?
Aerosolized NOS2 gene transfer increases pulmonary NO production and attenuates hypoxic pulmonary hypertension and vascular remodeling in a rat model.
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Hypothesis-generating for NOS2 gene therapy in hypoxic pulmonary hypertension; human studies needed before any clinical consideration.
Budts et al. (2000) studied this question.
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