Why the study?
Does nicotine nasal spray affect plasma levels of nitric oxide in smokers undergoing smoking cessation?
Population
40 smokers and 13 age-comparable never-smoker, non-nicotine user controls
Comparison
Nicotine nasal spray for 7 days vs Baseline (pretreatment) and never-smoker controls
Design
Cohort
Follow-up
7 days
Authors
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May sustain nitric oxide levels with nicotine nasal spray during cessation; hypothesis-generating for cardiovascular effects in larger studies.
Does nicotine nasal spray affect plasma levels of nitric oxide in smokers undergoing smoking cessation?
Nicotine use via nasal spray maintains elevated plasma nitric oxide levels independent of cigarette smoking.
Miller et al. (1998) studied this question.
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