Key result
Oral intake of 500 mg potassium nitrate elevated plasma nitrate from 29 to 313 mumol/l within 60 minutes, indicating dietary nitrate must be restricted for at least 48 hours to assess endogenous NO.
Why the study?
Can plasma nitrate be used as a reliable index of endogenous nitric oxide formation in humans?
Population
Humans
Comparison
Dietary nitrate manipulation, gastrointestinal… vs Baseline levels
Design
Other
Authors
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Plasma nitrate rises sharply after nitrate-rich meals; leaves open its validity as endogenous NO index without dietary control.
Can plasma nitrate be used as a reliable index of endogenous nitric oxide formation in humans?
Plasma nitrate can serve as a valid index of endogenous nitric oxide formation in humans only if dietary nitrate is strictly restricted for at least 48 hours due to its large distribution volume and low clearance.
Jungersten et al. (1996) studied this question. Potassium nitrate vs. Baseline was evaluated on Plasma nitrate concentration. Oral intake of 500 mg potassium nitrate elevated plasma nitrate from 29 to 313 mumol/l within 60 minutes, indicating dietary nitrate must be restricted for at least 48 hours to assess endogenous NO.
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