Key result
Plasma NOx concentrations do not reliably reflect nitric oxide formation in vivo, suggesting that high-molecular weight nitrosothiols like nitrosoalbumin may serve as alternative markers.
Design
Review
Authors
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Plasma NOx should not guide clinical nitric oxide assessment; leaves open validation of nitrosoalbumin as alternative marker.
Plasma NOx is an unreliable marker of in vivo nitric oxide formation due to confounding by elimination rates and contamination, highlighting the need for alternative markers like nitrosoalbumin.
Ishibashi et al. (2003) conducted a review in Endothelial dysfunction. Plasma NOx concentrations do not reliably reflect nitric oxide formation in vivo, suggesting that high-molecular weight nitrosothiols like nitrosoalbumin may serve as alternative markers.
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