Why the study?
Does predominantly total circulatory arrest increase the risk of early developmental difficulties compared to continuous low-flow cardiopulmonary bypass in children undergoing arterial switch operation for d-transposition of the great arteries?
Population
171 children with d-transposition of the great arteries undergoing repair by an arterial switch operation…
Comparison
Predominantly total circulatory arrest during… vs Predominantly continuous low-flow…
Design
RCT, Randomized
Follow-up
2.5 years
Authors
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Favors low-flow bypass over circulatory arrest in infant d-TGA repair to reduce early developmental risks; confirms perfusion strategy effects in this RCT.
Does predominantly total circulatory arrest increase the risk of early developmental difficulties compared to continuous low-flow cardiopulmonary bypass in children undergoing arterial switch operation for d-transposition of the great arteries?
The use of total circulatory arrest during infant open heart surgery for d-TGA may increase the risk of early developmental difficulties compared to low-flow cardiopulmonary bypass.
Bellinger et al. (1997) studied this question.
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