What question did this study set out to answer?

To compare the prevalence of microalbuminuria and cardiovascular risk factors between normal and high normal blood pressure categories in prehypertensive individuals.

January 1, 2007Circulation JournalOpen Access

Comparison of Microalbuminuria in 2 Blood Pressure Categories of Prehypertensive Subjects

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Why the study?

Does high normal blood pressure increase the prevalence of microalbuminuria compared to normal blood pressure in prehypertensive subjects?

Population

2,678 prehypertensive subjects (1,689 men, 989 women) with no history of diabetes or hypertension.

Comparison

High normal blood pressure vs Normal blood pressure

Design

Cross-sectional

Authors

BKByung Jin KimGeneral Cardiology HLHyun‐Jong LeeON Semiconductor (United States)KSKi‐Chul SungPreventive Cardiology

Discussion

Member takes

Implication

May signal elevated renal risk in high-normal BP; hypothesis-generating and should not change practice without prospective data.

Key Points

To compare the prevalence of microalbuminuria and cardiovascular risk factors between normal and high normal blood pressure categories in prehypertensive individuals.
Evaluated 2,678 prehypertensive participants (1,689 men, 989 women) without a history of diabetes or hypertension.
Measured morning urine albumin excretion using an immunoradiometric assay to detect microalbuminuria.
Compared subjects with normal BP (120–129/80–84 mmHg) against high normal BP (130–139/85–89 mmHg) using multiple logistic regression analysis.
Microalbuminuria prevalence was significantly higher in the high normal BP group than in the normal BP group (4.9% vs. 2.8%, p=0.009).
High normal BP was independently associated with microalbuminuria (OR=1.692, 95% CI 1.097–2.611).
Participants with high normal BP had a significantly higher prevalence of metabolic syndrome, higher triglycerides, fasting glucose, uric acid, and ferritin, and lower HDL-cholesterol.

Structured PICO

Does high normal blood pressure increase the prevalence of microalbuminuria compared to normal blood pressure in prehypertensive subjects?

Population

2,678 prehypertensive subjects (1,689 men, 989 women) with no history of diabetes or hypertension.

Intervention

High normal blood pressure (systolic 130-139 mmHg or diastolic 85-89 mmHg)

Comparator

Normal blood pressure (systolic 120-129 mmHg or diastolic 80-84 mmHg)

Outcome

Prevalence of microalbuminuriasurrogate

High normal blood pressure is independently associated with a higher prevalence of microalbuminuria and other cardiovascular risk factors compared to normal blood pressure in prehypertensive individuals.

Cite This Study

Kim et al. (2007) studied this question.

synapsesocial.com/papers/6a8a660fe456f7df1bc1424b https://doi.org/10.1253/circj.71.1283

Topics

Hypertension management Women and heart disease

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Comparison of Microalbuminuria in 2 Blood Pressure Categories of Prehypertensive Subjects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Comparison of Microalbuminuria in 2 Blood Pressure Categories of Prehypertensive Subjects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider