Population
Intact canine heart model
Design
Preclinical
Authors
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Pulsus alternans may arise from post-ischemic segmental contractile alternans in canines; leaves open mechanistic relevance to human disease.
In a canine model, transient LAD occlusion induces segmental contractile alternans that manifests as pulsus alternans, suggesting it is caused by alternate attenuation or potentiation of contraction.
Parmley et al. (1972) studied this question.
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