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June 1, 1997Clinical and Experimental Pharmacology and Physiology

Association Analysis of Six Candidate Genes in a Sample of Australian Hypertensive Patients

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Why the study?

Are six candidate genes associated with blood pressure status in Australian hypertensive patients?

Population

Australian hypertensive and normotensive subjects

Comparison

Six genetic markers for genes encoding… vs Normotensive subjects

Design

Case-control

Authors

PHP. R. HuggardThe University of QueenslandKSKim SummersTranslational Research InstituteJWJason WestSeoul National University of Science and Technology

Discussion

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Implication

Null results in this Australian cohort do not support these markers clinically; leaves open genetic roles in hypertension across populations.

Structured PICO

Are six candidate genes associated with blood pressure status in Australian hypertensive patients?

P
Population
Australian hypertensive and normotensive subjects
I
Intervention
Six genetic markers for genes encoding vasoconstrictors, growth factors and a structural protein of the extracellular matrix
C
Comparator
Normotensive subjects
O
Outcome
Association with blood pressure (BP) statussurrogate

This study found no association between six candidate genes related to vascular diameter and essential hypertension in an Australian cohort.

Cite This Study

Huggard et al. (1997) studied this question.

synapsesocial.com/papers/6a8a6659f030e20138de88a0https://doi.org/10.1111/j.1440-1681.1997.tb01224.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Independent, Marked Associations of Alleles of the Insulin Receptor and Dipeptidyl Carboxypeptidase-1 Genes with Essential Hypertension1993 · 43 citations
  2. 2Hypertension: Pathophysiology, Diagnosis, and Management1991 · 948 citations
  3. 3Role of Insulin Resistance in Human Disease1988 · 12,161 citations
  4. 4The angiotensin I converting enzyme gene and predisposition to high blood pressure.1993 · 233 citations